Cerebrovascular diseases (for example, ischemic stroke) are the second leading cause of death worldwide and this trend is expected to continue and even grow until 2030 [1]. Unfortunately, most people with stroke symptoms still do not get to the hospital in time. This hinders them from being considered for time-dependent treatments that can reduce disability or death. Such incidents show that the system of care for stroke victims can be improved. In the first 3 hours after a suspected cerebrovascular accident (CVA), non-contrast head computed tomography (CT) is the primary imaging modality for the differential diagnosis of acute stroke. However, the latest research shows significantly improved clinical outcomes in patients with acute stroke after lysis therapy with Alteplase even in the range of three to four and a half hours after the first stroke symptoms [2]. Based on these results we expect that using perfusion CT in addition could be even more beneficial in order to reduce serious adverse events and predict a beneficial outcome for these patients by looking at the relation between core infarct and tissue at risk. This has been not performed in this study and has to be proven in future studies.
CT perfusion imaging with syngo® Volume Perfusion CT Neuro can be used to diagnose acute ischemic stroke in the emergency department quicker than with magnetic resonance imaging (MRI), according to results of a large single-center study [2]. The study shows that CT perfusion had 100 percent accuracy for detecting the acute ischemic stroke (AIS). If adopted, the researchers say that this advancement in stroke detection will mean dramatically faster diagnosis times - less than half the time of MRI screening - and enable physicians to provide more accurate and targeted care, thereby avoiding potentially life-threatening complications that can occur when thrombolytic drug therapy is used inappropriately. The study also reveals that within five minutes of the patient getting on the CT scanner table, results can be achieved, as opposed to MRI, which takes half an hour. The study also reveals that the widespread use of CT perfusion is a practical way to help busy emergency departments to significantly save time in acute stroke diagnosis, target treatment, and reduce the risks of inappropriate thrombolytic use. According to the researchers, it is remarkable that the average time between an emergency room neurological exam and CT scan was only 35 minutes. They confirmed that CT perfusion imaging is very effective for diagnosing acute stroke and concluded that their result could change national stroke triage protocols.
Apart from the speed advantage, dynamic perfusion CT has become an increasingly accepted examination for the differential diagnosis of acute stroke patients. Multislice CT, with a continuously increasing number of detector rows, has quickly made high-resolution CTA of the cerebral vasculature a clinical routine examination. It has, however, not really overcome the limitations with respect to traditional CT perfusion imaging, which is restricted to the detector width. Innovative technology such as the unique Adaptive 4D Spiral mode of the Siemens SOMATOM® Definition family overcomes the limitations of static detector designs and now allows volume perfusion imaging of the whole brain in clinical routine.
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[1] World Health Statistics 2008
[2] The Role of CT Perfusion Imaging in Acute Stroke Diagnosis: A Large Single-Center Experience, Rai et al., The Journal of Emergency Medicine, Volume 35, Issue 3, Pages 237-354, October 2008)