Von Willebrand Disease Diagnosis with BC von Willebrand Reagent:
A von Willebrand Ristocetin Cofactor Assay is the most sensitive screening test for the determination of von Willebrand factor deficiencies. The Siemens Healthcare Diagnostics BC von Willebrand Reagent is an automated turbidimetric and standardized in vitro diagnostic assay for the quantitative determination of the ristocetin cofactor (RCo) activity of von Willebrand factor (VWF). Von Willebrand disease (VWD) is caused by qualitative and/or quantitative deficiencies of VWF. The prevalence of VWD is estimated to be approx. 1% without ethnic differences, and thus one of the most frequent causes that require bleeding disorder management.¹

The detection and characterization of VWD should take clinical assessment and laboratory evaluation into account, including Closure Time with PFA-100®, VWF:RCo, VWF Antigen (VWF:Ag), Factor VIII coagulation, VWF collagen binding assay and others as appropriate. The BC von Willebrand Reagent measures VWF activity, whereas the Siemens vWF Ag Assay (for use outside the United States) determines the VWF concentration in the sample. Both assays are important to distinguish quantitative (type 1 and 3) from qualitative (type 2) defects of VWF. In conclusion, precise diagnosis of VWD is required to determine the severity and subtype of VWD in order to indicate and enable appropriate patient therapy, especially prior to high risk surgery, and to prevent misdiagnosis in, e.g., women suffering from menorrhagia.

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Von Willebrand reagent Kits