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Dimension® Clinical Chemistry Systems - CSA/CSAE Assays
Siemens Healthcare Diagnostics is the only company to offer a no manual pretreatment cyclosporine assay for enhanced productivity in ISD testing.
Toxic side effects, a narrow window of therapeutic efficacy, and the need to maintain consistent drug levels in order to prevent organ rejection mean frequent CSA monitoring is required for patients who have undergone cardiac, renal, and liver transplants.1,2 With the Dimension systems’ CSA and CSAE assays, testing is available around the clock and results can be reported rapidly.
Features
- No manual sample pretreatment required
- Fully automated, onboard sample pretreatment
- Rapid results reporting with continuous barcode identification of samples and online transmission of results
- Limited cross-reactivity to CsA metabolites – highly specific to the CsA parent compound
- Extended assay range (CSAE) for effective C2 monitoring
Advantages
- Reduced risk for error with minimal sample handling
- No need for batch testing - perform CSA/CSAE testing alongside other routine chemistry assays any time, day or night
- Decreased manual labor for enhanced productivity
- Outstanding analytical performance for confidence in results
Assay Specifications
| Dimension Systems CSA Assay | Dimension Systems CSAE Assay | |
|---|---|---|
| Product Code | DF89A | DF108 |
| Sample Type | EDTA Whole Blood | EDTA Whole Blood |
| Pretreatment | Fully automated, onboard | Fully automated, onboard |
| Reportable Range | 25-500 ng/mL | 350-2000 ng/mL |
| Calibration Stability | 30 days or with new reagent lot | 30 days or with new reagent lot |
| Onboard Stability | Closed, onboard: 30 days Open well: 3 days |
Closed, onboard: 30 days Open well: 3 days |
Enduring Expertise for Your Immunosuppressant Drug Testing Needs.
With recognized drug testing expertise, Siemens Healthcare Diagnostics offers a comprehensive and expanding menu of tests across multiple instrument solutions to meet the immunosuppressant drug (ISD) testing needs of customers in any setting.
Learn more about the ISD offerings from Siemens
Learn more about organ transplantation
Learn more about ISD monitoring
Learn more about cyclosporine
References:
1. Hardman, JG, Limbird LE, Malinoff PB, Ruddon RW. The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw Hill; 1996.
2. Kaplan LA, Pesce AJ. Clinical Chemistry-Theory, Analysis, Correlation. 3rd ed. St. Louis, MO: Mosby; 1996.
