ADVIA Centaur® and ACS:180® Digoxin Assay

Siemens Healthcare Diagnostics offers a panel of Therapeutic Drug Monitoring (TDM) assays that meet the majority of any laboratory’s high volume TDM testing needs. This broad panel allows the consolidation of a greater number of your high volume TDM assays onto one immunoassay platform. Our TDM assays also deliver excellent performance which gives you confidence in reported results. All run on the most productive and adaptable instruments available ensuring greater throughput and flexibility.

ADVIA Centaur and ACS:180 – Proven Performance – Digoxin Assay

Excellent specificity
Low cross-reactivity to digoxin metabolites and DLIF
Low cross-reactivity to common steriods
Correlates well to existing methods
No sample pre-treatment required

Method Comparison – Excellent Correlation To ACS:180 And Competitive Method

ADVIA Centaur	ACS:180
ADVIA Centaur Digoxin = 0.99 (ACS:180 Digoxin) + 0.02 ng/mL	ACS:180 Digoxin = 1.04 (FPIA+) - 0.07 ng/mL
Correlation coefficient (r) = 0.99, n = 323	Correlation coefficient (r) = 0.95, n = 358
Range of Analyte Concentration = 0.17 - 4.60 ng/mL	Range of Analyte Concentration = 0.4 - 3.6 ng/mL

Workstation Consolidation

Consolidate TDM testing onto a single platform and improve the productivity of your laboratory.
Broad menu of TDM assays available on both the ADVIA Centaur and ACS:180 including: Carbamazepine, Cyclosporine*, Digitoxin, Digoxin, Gentamicin, Phenobarbital, Phenytoin, Theophylline, Tobramycin, Valproic Acid, Vancomycin

Digoxin Assay Specifications

	ADVIA Centaur	ACS:180
Sample Type	Serum	Serum
Sample Volume	50µl	50µl
Assay Range	0.1 - 5.0 ng/mL (0.218 - 6.4 nmol/L)	0.1 - 5.0 ng/mL (0.218 - 6.4 nmol/L)
Analytical Sensitivity	0.1 ng/mL (0.218 nmol/L)	0.1 ng/mL (0.218 nmol/L)
Calibration Interval	28 days/3 days	7 days
On-Board Stability	3 days/28 days	40 Hours

* In development

Assay availability subject to local regulatory requirements.

For detailed information on this test, including limitations or interferences that may affect the interpretation of test results, contact your clinical laboratory or Siemens Healthcare Diagnostics.