Gebruik van cookies
In deze website wordt gebruik gemaakt van sessie-, permanente en first party tracking cookies. Voor het plaatsen daarvan is uw toestemming nodig.
Indien u geen toestemming geeft, kunt u de website niet openen. Er wordt gewerkt aan een oplossing om de website ook zonder gebruik van cookies beschikbaar te stellen.
Lees hier meer over de in deze website gebruikte cookies
Organ transplantation constitutes the transfer of organs, tissues or human cells from a healthy person (donor) to an individual with a damaged or failing organ (recipient), in order to maintain normal physiologic function.1
References about organ transplantation are found in medical literature as early as 800 BC with the first documented solid organ transplant occurring in the early 1900s. Since then, advances in surgical techniques, tissue typing, and immunosuppressive drug therapy have improved the success rates of organ transplantation.
Transplants can be broadly categorized into the following:
A very real concern in organ transplantation is the possibility of transplant rejection. Rejection is a complex response to the transplanted tissue and involves several components of the immune system, such as lymphocytes, cytokines, and macrophages, which recognize the transplanted organ as a foreign substance and try to eliminate it from the body. The immune response subsequently leads to local inflammatory injury and graft damage.1
Depending on the time of onset and pathogenesis, rejection can be classified into 3 distinct categories:
A key element in preventing organ rejection is the use of immunosuppressant drugs (ISDs). ISDs can be administered as a countermeasure to suppress the host’s immune response. However, regular monitoring of immunosuppressant drug concentrations is imperative to prevent infections and malignancies that occur as a result of the suppressed immune system. In addition, ISD monitoring is essential to maintain the balance between the appropriate therapeutic drug levels necessary to prevent organ rejection with the potential toxic side effects that accompany ISD therapy.
To optimize transplantation outcomes, regular monitoring of various pre- and post-transplant factors is vital. Some of the routine monitoring tests conducted include the following:
Routine pre- and post-transplant tests: Complete blood count, chemistry screening panel, blood pressure, echocardiogram, electrocardiogram (ECG), mammogram, bronchoscopy, pulmonary function test (PFT), ultrasonography and biopsies
Pre- and post-transplant serological screening for infectious diseases: Human immunodeficiency virus (HIV), hepatitis A, B, and C viruses, cytomegalovirus (CMV), herpes simplex virus, Epstein-Barr virus (EBV), toxoplasmosis, and varicella-zoster virus and measles virus (in pediatric patients)
Monitoring for organ function: Tests for monitoring toxic side effects of immunosuppressive drugs and the graft function for some of the organs include:
With recognized drug testing expertise, Siemens Healthcare Diagnostics offers a comprehensive and expanding menu of tests across multiple instrument solutions to meet the immunosuppressant drug (ISD) testing needs of customers in any setting.
Learn more about our complete menu of ISD assays