Explora CN

The Siemens Explora® family of radiochemistry modules offers a comprehensive line of products for efficient PET compound preparation. All modules are computer controlled using a Windows®-based graphical user interface, offering both convenience and flexibility.

The Explora CN uses simple, effective flow chemistry for robust production of ¹¹C-HCN. The unit also includes conversion of ¹¹C carbon dioxide to methane.

Process Description
¹¹C-CO₂, produced by the proton irradiation of N2 gas mixed with O₂, exits the target first by its own pressure, then by helium flow. In the module, the gas from the target passes through a 400 °C furnace containing a Ni/NiO catalyst. In this furnace the ¹¹C-CO₂ is reduced to ¹¹C-CH₄ with H₂ gas. If desired, the ¹¹C-CH₄ may be used directly from the module for further synthesis steps in other modules or by manual methods.

To produce ¹¹C-HCN, the ¹¹C-CH₄ is passed through an Oxisorb™ trap, which removes water and oxygen. Gaseous NH₃ is added, and the mixture passes through a second furnace, containing a platinum catalyst at 950 °C. This converts ¹¹C-CH₄ to ¹¹C-HCN, which exits the module for subsequent use.

Documents
  Data Sheet[91 KB]