Explora AC

The Siemens Explora® family of radiochemistry modules offers a comprehensive line of products for efficient PET compound preparation. All modules are computer controlled using a Windows®-based graphical user interface, offering both convenience and flexibility.

The Explora AC can be used to synthesize ¹¹C-acetate or other Gringard based products. The starting material for all syntheses is ¹¹C-CO₂, which is bubbled through a solution of the active agent. Distillation and/or other purification steps are used to ensure the purity of the final product.

The Explora AC Acetate module is flexible and hence capable to perform Grignard-based chemistry. The module uses small reaction volumes (e.g., 200 µl of solvent for the bubbling of ¹¹C-CO₂) and inexpensive, readily available components.

Acetate Process Description

The Explora AC delivers a buffered solution of ¹¹C-acetate. The process is a two-step method utilizing methyl magnesium bromide followed by neutralization with phosphoric acid (H₃PO₄).

Documents
  Data Sheet[98 KB]